Due to its favorable pharmacokinetic features, midazolam is being considered as a replacement anticonvulsant for diazepam in the antidote kit for nerve agents. Midazolam is administered intravenously or intramuscularly to control acute seizures and SE.
It potentiates GABAergic inhibition and thereby controls hyperexcitability and seizures. Midazolam is a positive allosteric modulator of synaptic γ‐aminobutyric acid (GABA)A receptors in the brain. Midazolam is a benzodiazepine hypnotic with a rapid onset and short duration of action.ResultsMidazolam is considered the new drug of choice for persistent acute seizures and SE, including those caused by neurotoxic OPs and nerve agents. SummaryObjectiveThis review summarizes the therapeutic potential of midazolam as an anticonvulsant antidote for organophosphate (OP) intoxication.MethodsBenzodiazepines are widely used to treat acute seizures and status epilepticus (SE), a neurologic emergency of persistent seizures that can lead to severe neuronal damage or death.
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